Also on Friday, Grande met privately with some of those who lost loved ones in the May 22 attack, including parents of Martyn Hett, 29, and Courtney Boyle, 19.
The rest of the tickets to the show at the Emirates Old Trafford Cricket Ground, which has a capacity of about 50,000, sold out within minutes.
Ariana also performed "The Way" in a duet with her rapper boyfriend Mac Miller.
Grande canceled upcoming shows in London and Switzerland to prepare for Sunday's "One Love Manchester" concert.
"Together we will stand and we'll hold your hand". All proceeds from the event will go to the victims and their families.
British singer Marcus Mumford held a moment of silence before opening the benefit concert.
Headliner Grande was a perpetual presence throughout, performing solo hits as well as joining other artists, including hitting the stage with Black Eyed Peas for a stirring take on "Where is the Love", filling in for Fergie.
The attack killed 22 people and injured more than 100 others. The attack killed 22 and wounded dozens.
Liam Gallagher then came out and performed his band's 1994 hit "Live Forever", but fans hoping for an Oasis reunion were disappointed when Martin joined him on stage instead of estranged brother Noel Gallagher.
Last week, she returned to the United Kingdom, where she visited Manchester suicide bombing survivors in the hospital and prepared for the One Love Manchester show, which will also feature the likes of Justin Bieber, Katy Perry and Coldplay and be televised live on Sunday at 2pm on channels such as ABC and BBC, plus online.
Fans Stacie Richardson and James Bend say there were shaken after the May 22 attack at Manchester Arena.
Richardson says "Ariana is very fearless to come back so soon".
They say the vehicle and knife rampage in London on Saturday did little to ease their worries. "Just as I was about to leave the room, Adam looked at me and he said, 'Hey, Scooter, make sure you tell them, 'Don't go forward in anger, love spreads.' Adam, if you're watching, you're our hero tonight".
Justin Bieber's two-song acoustic set of "Love Yourself" and "Cold Water" galvanized the crowd, ending as the pop star praised the resilience of the city and the fans between sobs.
Some of the biggest names in the music industry came together to honour the victims of the Manchester terror attack with a special benefit concert on Sunday (4 June) night.