Huddersfield, whose last season in the top-flight was 1971-72, play Crystal Palace.
The first North London Derby will be at Ashburton Grove on November 18th.
The first Manchester derby of the season will be played at Old Trafford on 9th December, the same weekend that will see Liverpool host Everton at Anfield in the first Merseyside derby.
Huddersfield will hope to have secured survival before their final four games, given they're against Chelsea (a), Everton (h), Man City (a) and Arsenal (h).
This year there is no Champions League football to derail them, but the fixture computer has made up for that by pitting the Gunners against Everton, Spurs and Man City.
Liverpool FC 2017-18 Premier League fixtures see Reds handed nice start and finish Posted by Andy Morris
Local rivals Manchester United are 10-3 second favourites, with champions Chelsea a 7-2 shot.
- Brighton have won just one of their last five opening fixtures to a league season (D1 L3).
"One possibility is that the Southampton fixture will be reversed, with Slaven Bilic's side scheduled to visit St Mary's on 31 March, meaning that West Ham would play their first three games away from home".
December could also be another rough month, as we face Manchester United to start the month, plus Liverpool on the 23rd.
Since City's Qatari-windfall, the clubs have developed a competitive rivalry, based partly on a feeling in North London that Spurs' would have enjoyed considerably more recent success had City not struck gold. United, United vs. Everton and Spurs vs. City, meanwhile, face four away games following their six European games.
West Ham faces playing its first three games away from its home at the London Stadium _ the centerpiece of the 2012 Olympics _ because the venue will be hosting the world athletics championship from August 4-13. All stated dates are Saturdays and are therefore subject to change once games are chosen for live television. "Supporters are therefore advised that our second fixture of the campaign, against Southampton, will be rescheduled, with further details to follow".