The Republican victor of the most expensive House race ever took her seat representing Atlanta's outskirts Monday evening, along with a South Carolina Republican who claimed a narrower-than-expected victory to retain a strongly Republican seat.
Pelosi has been under fire by critics in her party who look to the recent special elections - in which Democrats lost to Republicans in all four cases - as a further sign that it is time for new party leadership.
Handel defeated Democrat Jon Ossoff in the most expensive congressional election in history, with spending expected to have topped $50 million.
Republican Ralph Norman, a staunch conservative, had a 3 percentage point victory last week in a far quieter SC race in a district that went for President Donald Trump past year by 18 percentage points.
So, Pelosi said, she replied, "Mr. President, that isn't true and there's no evidence, facts or data to support what you're saying".
"Don't tell anybody I told you this", she joked to Reid. The Georgia seat went only narrowly for Trump past year, even though it strongly backed Tom Price, who resigned to become secretary of the Department of Health and Human Services.
The new polling numbers represent more bad news for House Minority Leader Nancy Pelosi, who is facing calls to step down in the wake of four straight losses in special elections for Democrats, as well as Senate Minority Leader Chuck Schumer, who recently admitted that Democrats lack any sort of real message.
Pelosi, 77, said there's no room to fix the legislation and instead Democrats and Republicans should focus on improving Obamacare, "instead of sabotaging it", she said.
"I've always had a challenge in the caucus right from the start", she said.
The California Democrat then asked the crowd, "Why so insecure?"