The actor approached a bystander and a police officer asking for a cigarette, according to a statement from the Savannah-Chatham Metropolitan Police Department.
He was told to leave the area but refused and became aggressive toward the officer, police said. The actor, who has faced repeated and embarrassing legal drama, often related to public intoxication, has recently been filming his upcoming flick The Peanut Butter Falcon in Savannah.
During a red carpet premiere in 2014, the internationally recognised LaBeouf wore a brown paper bag on his head that read "I Am Not Famous Anymore".
Shia was taken into custody at 4 A.M. Saturday morning. When the officer decided that enough was enough and attempted to place the former child star under arrest, Shia LaBeouf reportedly fled the scene.
He eventually ran off, into a nearby hotel, and was later apprehended in the lobby. The Transformers actor was arrested in 2014 after he disrupted a Cabaret performance in NY. A spokeswoman for LaBeouf, 31, did not return a call or e-mail seeking comment.