But with Mauricio Pochettino's side piling on the pressure in the closing stages against his former club, the Argentine will consider this a missed opportunity in Spurs' hunt for a Champions League place.
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The match will be held at St. Mary's Stadium.
However, he is in line to join in with the first-team training session on Saturday and could be ready to play in Wales a week later.
"Hopefully next week will be a good week for us but in the market, everything can change in one second", said the Saint boss.
Southampton remain in the Premier League's bottom three after a 1-1 draw at home to Tottenham on Sunday, Harry Kane scoring the equaliser.
While Harry Kane grabs the headlines for his goalscoring exploits, the former Bayer Leverkusen forwards work could easily go unnoticed to the less attentive fan.
Dele Alli had been involved in eight goals in four previous Premier League games against Southampton, but he dragged a shot wide after 64 minutes.
The pair played together for their country and Barcelona but Pellegrino says he turns to mentor Rafael Benitez, and not Pochettino, in the dark times.
Following a momentum-stalling draw with West Ham, Mauricio Pochettino's men have comfortably beaten Wimbledon 3-0 in the FA Cup and trounced Everton 4-0 in the Premier League. "It was a great experience in Sheffield and we made a quick decision to move [him] to Ipswich. There were massive chances we had in the last minute with Harry Kane but at the end if you analyse the game it's a fair result".
"If we are in this situation now, and no one new is here, it is because we are pushing to try to bring in good players and good players are hard to bring in".