All three of the designated road teams will be making their first trip to London for a regular-season game.
"We continue to be very excited by the growth of the NFL in the UK", NFL Commissioner Roger Goodell said in a statement.
The NFL will send six teams to London in the fall as a new survey indicates that British people find the sport second only to golf as the dullest to watch. No decision has been made as to whether the Jaguars will have their Bye Week immediately following the game against Philadelphia in London.
Eagles fans can rest assured knowing that the game will be one of the Jaguars' home games that will be moved, meaning there will still be eight home dates at Lincoln Financial Field in 2018.
It's impossible to predict in January which teams will be good in October, but all three London games that were announced on Thursday should be good matchups.
From 1994 to 1999, the Chargers played three preseason games as part of the NFL's American Bowl series, against the New York Giants in Berlin in 1994, the Pittsburgh Steelers in Tokyo in 1996 and the Denver Broncos in Sydney, Australia, in 1999.
The Chargers, who went 9-7 but missed the playoffs in their return to Los Angeles this season, will also play internationally in 2019, at a location to be determined.
One of those fixtures will be played on 21 October and the other on 28 October, with the decision on that still to be taken. "Nobody in the United Kingdom needs to worry about our commitment; [it is a] unique year for us". This enables us to achieve important learnings relating to the fans' preferences, ticketing, team logistics and local transportation and infrastructure in order to create the best possible experience and environment.
"Spurs' new ground will stage one game in its first year of opening and in 2019 we look forward to going back to staging at least four National Football League games in London".
Tottenham has signed a 10-year contract for games with the NFL.
"When we played the first game here we had no idea if we were ever coming back", Waller said.