The Premier League leaders have a home clash with Watford on Tuesday.
Manchester City manager Pep Guardiola says he is unsure when David Silva will return after admitting the Spaniard is unavailable for "personal reasons". "It's the only thing I ask". "It's OK. But there are limits".
De Bruyne shot straight at Hennessey and then saw an effort blocked by Martin Kelly but, despite dominating possession, City struggled to find openings in a well-drilled Palace backline.
Alexis Sanchez and Pep Guardiola could reunite this January.
United allowed a 14-point lead in December 1993 to be completely erased by Blackburn by April 1994, but the Old Trafford outfit recovered to win the title that season regardless and City now have such a cushion that it would take a huge collapse, and a long winning run by Chelsea or United, for them to finish anywhere but top.
Despite failing to score for the first time in 21 league games, City remains well ahead of the pack.
But the inevitable focus on the consequences of Sunday's match for City could not diminish the achievement for its opponent. However, their winning streak was halted at 18 by the resolute Palace.
Palace battled admirably against a star-filled side averaging almost three goals a game and had to overcome its own injury loss - Palace captain Scott Dann also left the match on a stretcher after an earlier foul on De Bruyne - as well as City's sustained second-half pressure.
"I don't know (what's going to happen) but he's a player of Arsenal and I think he is going to stay there", Guardiola added. Defensively Manchester City also have some injuries with captain Vincent Kompany, Mendy and Delph all look likely to miss this game. "My feeling now is Alexis is an Arsenal player".
Guardiola defended his side's rare slip-up, insisting dropping points was always going to happen. "I'm not thinking about to be unbeatable".