Now this time-fresh season is started and will grab the advantage of the absence of Ab-de-Villiers in first three One-Day's and Skipper Faf-de-Plessis, who scored the fabulous hundred against India in the first One-Day.
While the hosts didn't rename a replacement for de Kock, young keeper Heinrich Klaasen, who finished as the third highest run-getter in South Africa's domestic one-day tournament, is expected to make his ODI debut.
"Quinton suffered an extreme blow to the left wrist while batting in the second ODI on Sunday and felt severe pain and discomfort", team manager Mohammed Moosajee said in a Cricket South Africa statement.
"This type of injury will require between two to four weeks to heal, which subsequently rules him out of the remainder of the ODI and T20 series against India".
India wins both matches comfortably, Run Machine-Kohli completed his 33rd ODI hundred and completed his 9000 INTL runs in the first ODI of this series which helps India to win this match by 6 wickets.
South Africa might be tempted to play a fast bowler in place of Tabraiz Shamsi, but given the conditions at Cape Town, they might just give him another shot at redemption.
The leg-spinning duo of Yuzvendra Chahal and Kuldeep Yadav has put the hosts under real pressure during the first two matches, claiming 13 wickets in the process. After getting out of this series of Du Plessis, Inexperienced Aiden Makaram will lead South Africa in the 3rd ODI but it is too hard for him to manage his team and register their first win in this series.
South Africa will hope, though, that De Kock's enforced break proves to be a blessing in disguise.
Overall, the best partnership for South Africa has only been 76 for the sixth wicket between Du Plessis and Chris Morris at Kingsmead. India has lost two of three matches against South Africa here and one has won.
Where to get live TV of India vs South Africa, 3rd ODI, Cape Town? De Kock's current mindset certainly came under scrutiny after the first ODI at Kingsmead when he walked off without reviewing an lbw decision off Chahal.