Defenders Sam Byram and Winston Reid are injured, whilst James Collins and Angelo Ogbonna are also doubts.
While the Hammers have struggled on the road, their home form under Moyes has kept them out of the mire with a solid record of W3 D4 L1.
Chelsea hosts Crystal Palace in the late game Saturday.
Chris Wood came on to set up Barnes' goal and the New Zealand global added a brace of his own, each strike prompting additional ugly scenes, with some young children taking refuge on the Burnley bench to apparently escape unrest in the stands. This is not a good atmosphere for a club to have as they enter a game.
As with the majority of Burnley's games, there is unlikely to be many goals shared between the two sides. They just want to see their team win.
Burnley striker Wood said: "It was a tough situation - I can sympathise with how the fans feel, they are passionate supporters and it is tough for them at the moment but they need to stick with their players".
"Up until the goal you wouldn't have thought that it would have been such a bad day", West Ham boss Moyes told BBC Sport.
David Moyes' West Ham are in 16th place, three points from the bottom three.
Lee Mason is not a regular on the Premier League list - this is his first match in four weeks - but he has the lowest card count, with no more than two yellows in eight of his 13 games this season.
Chris Wood is making up for lost time in the English Premier League, playing a starring role in a tension-filled 3-0 win over West Ham in London.